Senior Research Manager Jaline Gerardin, PhD, highlights IDM's work in modeling drug campaigns for malaria using a simulated population to determine if a focal treatment strategy would prevent over-treatment and ultimately lead to malaria elimination.
Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study
Angela Devine, Katherine E. Battle, Niamh Meagher, Rosalind E. Howes, Saber Dini, Peter W. Gething, Julie A. Simpson, Ric N. Price, Yoel Lubellkbattle PLOS Medicine Research Malaria Thursday, August 5, 2021 - 21:36
A microplanning model to improve door-to-door health service delivery: the case of Seasonal Malaria Chemoprevention in Sub-Saharan African villages
Malaria incidence has plateaued in Sub-Saharan Africa despite Seasonal Malaria Chemoprevention’s (SMC) introduction. Community health workers (CHW) use a door-to-door delivery strategy to treat children with SMC drugs, but for SMC to be as effective as in clinical trials, coverage must be high over successive seasons.Read more aouedraogo ewenger BMC Health Services Research Research Malaria Wednesday, December 9, 2020 - 20:58
Vector genetics, insecticide resistance and gene drives: an agent-based modeling approach to evaluate malaria transmission and elimination
Vector control has been a key component in the fight against malaria for decades, and chemical insecticides are critical to the success of vector control programs worldwide. However, increasing resistance to insecticides threatens to undermine these efforts. Understanding the evolution and propagation of resistance is thus imperative to mitigating loss of intervention effectiveness. Additionally, accelerated research and development of new tools that can be deployed alongside existing vector control strategies is key to eradicating malaria in the near future.Read more pselvaraj ewenger dbridenbecker jorussel cbever BioRxiv Research Malaria Monday, March 16, 2020 - 17:30
Using mid-infrared spectroscopy and supervised machine-learning to identify vertebrate blood meals in the malaria vector, Anopheles arabiensisThe propensity of different Anopheles mosquitoes to bite humans instead of other vertebrates influences their capacity to transmit pathogens to humans. Unfortunately, determining proportions of mosquitoes that have fed on humans, i.e. Human Blood Index (HBI), currently requires expensive and time-consuming laboratory procedures involving enzyme-linked immunosorbent assays (ELISA) or polymerase chain reactions (PCR). Read more Emmanuel P. Mwanga, Salum A. Mapua, Doreen J. Siria, Halfan S. Ngowo, Francis Nangacha, Joseph Mgando, Francesco Baldini, Mario González Jiménez, Heather M. Ferguson, Klaas Wynne, Prashanth Selvaraj, Simon A. Babayan & Fredros O. Okumu pselvaraj Malaria Journal Research Malaria Monday, March 16, 2020 - 18:15
Detection of malaria parasites in dried human blood spots using mid-infrared spectroscopy and logistic regression analysisEpidemiological surveys of malaria currently rely on microscopy, polymerase chain reaction assays (PCR) or rapid diagnostic test kits for Plasmodium infections (RDTs). This study investigated whether mid-infrared (MIR) spectroscopy coupled with supervised machine learning could constitute an alternative method for rapid malaria screening, directly from dried human blood spots. Read more Emmanuel P. Mwanga, Elihaika G. Minja, Emmanuel Mrimi, Mario González Jiménez, Johnson K. Swai, Said Abbasi, Halfan S. Ngowo, Doreen J. Siria, Salum Mapua, Caleb Stica, Marta F. Maia, Ally Olotu, Maggy T. Sikulu-Lord, Francesco Baldini, Heather M. Ferguson, Klaas Wynne, Prashanth Selvaraj, Simon A. Babayan & Fredros O. Okumu pselvaraj Malaria Journal Research Malaria Monday, March 16, 2020 - 18:13
Reducing malaria burden and accelerating elimination with long-lasting systemic insecticides: a modelling study of three potential use cases
While bed nets and insecticide spraying have had significant impact on malaria burden in many endemic regions, outdoor vector feeding and insecticide resistance may ultimately limit their contribution to elimination and control campaigns. Complementary vector control methods such as endectocides or systemic insecticides, where humans or animals are treated with drugs that kill mosquitoes upon ingestion via blood meal, are therefore generating much interest.Read more pselvaraj jsuresh ewenger cbever Malaria Journal Research Malaria Monday, March 16, 2020 - 18:20
Senior Research Manager Caitlin Bever, PhD, discusses the challenges of preventing and treating malaria and how modeling plays a role in determining which interventions would be the most effective for a particular country.