HPVsim

  • The role of HPV single-dose vaccination in expanding access in GAVI-supported countries during a period of supply constraints

    Background: Over 2023 and 2024, 19 of the countries that were supported by Gavi to purchase HPV vaccines adopted a single-dose HPV vaccination schedule. The goal of this study is to estimate the impact on vaccination access and the number of cervical cancers averted compared to a two-dose schedule. Methods: We estimated the population that…

  • Can pruning improve agent-based models’ calibration? An application to HPVsim

    Agent-Based Models (ABMs) have gained popularity over the COVID-19 epidemic, but their efficient calibration remains challenging. Here we propose a novel calibration architecture by investigating the role of pruning in ABM calibration. We use a recently developed model for human papillomavirus (HPV) transmission and focus on its integrated calibration framework, Optuna. Simulating six synthetic datasets…

  • HPVsim: An agent-based model of HPV transmission and cervical disease

    In 2020, the WHO launched its first global strategy to accelerate the elimination of cervical cancer, outlining an ambitious set of targets for countries to achieve over the next decade. At the same time, new tools, technologies, and strategies are in the pipeline that may improve screening performance, expand the reach of prophylactic vaccines, and…