HIV Leaky Vaccine

Dashboard to explore exposure heterogeniety and HIV vaccine efficacy

The Leaky Vaccine dashboard is an online tool to explore the effects of exposure heterogeneity on HIV vaccine efficacy, given a leaky vaccine.

A potential outcome of pathogen exposure heterogeneity (i.e. variation among individuals in the risk of getting infected) is that vaccine efficacy measured from a trial (i.e. the clinical efficacy) is lower than the biological vaccine efficacy (i.e. the per-exposure or per-contact vaccine efficacy). This distinction, between the per-exposure vaccine efficacy and the clinical efficacy of the same vaccine, is the focus of this tool.