The Leaky Vaccine dashboard is an online tool to explore the effects of exposure heterogeneity on HIV vaccine efficacy, given a leaky vaccine.
A potential outcome of pathogen exposure heterogeneity (i.e. variation among individuals in the risk of getting infected) is that vaccine efficacy measured from a trial (i.e. the clinical efficacy) is lower than the biological vaccine efficacy (i.e. the per-exposure or per-contact vaccine efficacy). This distinction, between the per-exposure vaccine efficacy and the clinical efficacy of the same vaccine, is the focus of this tool.